THE NEW YORK TIMES BESTSELLER NOW A MAJOR FILM, STARRING STEVE CARELL AND BAFTA AND GOLDEN GLOBE NOMINATED TIMOTHEE CHALAMET ‘It was like being in a car with the gas pedal slammed down to the floor and nothing to do but hold on and pretend to have some semblance of control. But control was something I'd lost a long time ago.’ Nic Sheff was drunk for the first time at age 11. In the years that followed, he would regularly smoke pot, do cocaine and ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling true story of his relapse and the road to recovery. He paints an extraordinary picture for us of a person at odds with his past, with his family, with his substances, and with himself. Tweak is a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery and complements his father’s parallel memoir, Beautiful Boy. Praise for Nic Sheff:- ‘Difficult to read and impossible to put down.’Chicago Tribune 'Nic Sheff's wrenching tale is told with electrifying honesty and insight.' Armistead Maupin
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Improving teaching is the key to genuine and sustainable school improvement. Improvement involves persuading teachers to change and develop their practice but, as anyone who has ever tried will testify, this is far from easy. The focus of Tweak to Transform is what head teachers and school leaders can do to manage the change process and improve the quality of teaching in a school. Essentially, Tweak to Transform is a practical handbook that seeks to address three questions. What do we know about change? What do we know about learning? What do we know about leading and managing the improvement process? While there is no single successful recipe for improving teaching in a school, this book attempts to establish some key principles. The result is a collection of thoughts, activities strategies and models that have been developed and successfully implemented in a wide range of schools. >
As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In Tweak it, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes -- tweaks -- that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.
Regulation of Tissue Responses The TWEAK Fn14 Pathway and other TNF TNFR Superfamily Members that Activate Noncanonical NFkB Signaling
- Author : Linda C. Burkly
- Publisher : Frontiers Media SA
- Release Date : 2016-01-21
- Genre : Uncategorized
- Pages : 231
- ISBN : 9782889197002
The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signalin
In the multi-verse there exists those that would tamper with the realities of your world. They have the technology to change everything and anything. They even get to decide if you were ever born. They are a nasty sort with out a speck of compassion. There are others bent on balance with the same technology so who is really running the universe?
Little Elephant and Mama Elephant are going for a walk. “Hold on to my tail,” says Mama. “If you want to ask me a question, tweak twice.” Tweak, tweak! “Mama, what is that?” Little Elephant is curious about the frog, the monkey, the songbird, the butterfly, and the crocodile—and especially about what a little elephant can do. Mama knows just how to answer, to help her cherished Little Elephant grow. Eve Bunting’s tender text and Sergio Ruzzier’s whimsical illustrations make this walk with Mama an excursion any little elephant would enjoy.
Tweak It and Freak It A Killer Guide to Making Windows Run Your Way Hundreds of millions of people use Windows every day, and it’s a safe bet that some of them would not describe themselves as happy campers. Regardless of skill level, most people have something they dislike about Windows, and they often have a whole laundry list of Windows gripes. “Why can’t Windows do this rather than that?” “Why does Windows do X instead of Y?” “Wouldn’t it be great if Windows could do Z?” Most people think Windows is set in stone, but it isn’t! Strip off that veneer and a whole world comes into view, one that’s hackable, moddable, tweakable, customizable, and personalizable. This book shows you the tools and technologies that anyone can use to hack almost every aspect of Windows, from startup to shutdown, from the interface to the Internet, from security to scripting. • Speed up your tired PC with a fistful of easy-to-do, but oh so powerful tweaks! • Tired of looking at the same old Windows day in and day out? So are we! That’s why we show you how to give Windows a makeover! • Want to be more productive at work or home? This book is full of productivity tweaks that not only make Windows more fun to use, but also save you tons of time. • Create custom backup routines that safeguard your precious data. • Tighten the security of your PC and your network to stop would-be thieves in their tracks. • Dual-boot Windows XP and Vista on the same machine, or dare we say it, run MacOS on your PC! We won’t tell. Paul McFedries is a passionate computer tinkerer and Windows expert. He is the author of more than 60 computer books that have sold more than 3 million copies worldwide. His recent titles include the Sams Publishing books Windows Vista Unleashed, Second Edition, and Windows Home Server Unleashed, and the Que Publishing books Build It. Fix It. Own It. : Networking with Windows Vista, Formulas and Functions with Microsoft Excel 2007, Tricks of the M
You want a different perspective on old ideas. Youre open to a new way of thinking about your business, and youd like to be creatively provoked. Perhaps youve hit a roadblock in your communications, or you want something entertaining but relevant to help you see your career through another lens. Tweak Your Flash is simply about perspective; viewing your surroundings from a different angle will uncover nuances that otherwise go unnoticed. Looking at how a bird approaches a landing, or why a day with a favorite uncle holds such fond memories, can be applied to your professional life and make you more effective and fulfilled in your work. This is a book to be read and used over time; keep it handy, and reference it every now and then. Accepting for a moment that youre not as good at your job as youll ever be, use these ideas to ensure youre flashing the right message, at the right frequency, to the right people.
This is an adventure story set in the People's Republic of China in the early eighties before the nation was opened to the Western world. An engineer, Toby, from Hong Kong follows his mentally disturbed brother who has entered China. He fears the worst: illegal entry without a passport to be sure but perhaps also an act against China itself. Toby's colleague, Donna, his lover, helps in his quest while a mysterious college student, Kathy, invades the scene. The path leads deep into China. The story is a vivid picture of what the country and its people were like in the seventies: full of intrigue under a totalitarian regime. Guangzhou, Guilin, the Yangtze, and Chongking lead to Beijing and a triple-whammy ending.
- Author : Avital Schurr
- Publisher : Frontiers Media SA
- Release Date : 2015-07-08
- Genre : Uncategorized
- Pages : 231
- ISBN : 9782889195862
Glycolysis, the pathway of enzymatic reactions responsible for the breakdown of glucose into two trioses and further into pyruvate or lactate, was elucidated in 1940. For more than seven decades, it has been taught precisely the way its sequence was proposed by Embden, Meyerhof and Parnas. Accordingly, two outcomes of this pathway were proposed, an aerobic glycolysis, with pyruvate as its final product, and an anaerobic glycolysis, identical to the aerobic one, except for an additional reaction, where pyruvate is reduced to lactate. Several studies in the 1980s have shown that both muscle and brain tissues can oxidize and utilize lactate as an energy substrate, challenging this monocarboxylate’s reputation as a useless end-product of anaerobic glycolysis. These findings were met with great skepticism about the idea that lactate could be playing a role in bioenergetics. In the past quarter of a century monocarboxylate transporters (MCTs) were identified and localized in both cellular and mitochondrial membranes. A lactate receptor has been identified. Direct and indirect evidence now indicate that the enzyme lactate dehydrogenase (LDH) resides not only in the cytosol, as part of the glycolytic pathway machinery, but also in the mitochondrial outer membrane. The mitochondrial form of the enzyme oxidizes lactate to pyruvate and concomitantly produces the reducing agent NADH. These findings have shed light on a major drawback of the originally proposed aerobic version of the glycolytic pathway i.e., its inability to regenerate NAD+, as opposed to anaerobic glycolysis that features the cyclical ability of regenerating NAD+ upon pyruvate reduction to lactate by the cytosolic form of LDH. The malate-aspartate shuttle (MAS), a major redox shuttle in the brain, was proposed as an alternative pathway for NAD+ generation for aerobic glycolysis. Nonetheless, would MAS really be necessary for that function if glycolysis always proceeds to the end-products, lactate and NAD+? An
- Author : Dale Carnegie
- Publisher : Lulu Press, Inc
- Release Date : 2019-02-13
- Genre : Business & Economics
- Pages : 231
- ISBN : 9780359426591
A great business leader is a many-sided person who has a lot of strengths and capabilities. He may manage budgets, spearhead marketing campaigns, plan products, network with industry experts, and assess contract management software. He’s dedicated, industrious, bright, and creative. However even with all these admonitory qualities, a business leader is really only a leader if he likewise has one crucial trait: motivation skills. As a matter of fact, regardless your walk of life, if you seek to be a successful leader you have to be able to motivate those individuals who follow your guidance.
The new book about modular synths, their makers, and masters. Patching secrets, performance tips, history, modules, and techniques. Enthusiasts call it ?The definite modular bible!?00PATCH & TWEAK provides an opportunity for new and experienced users to become true masters of their modular systems by exploring, explaining, and demystifying a range of topics relevant to anyone interested in modular synths or just synthesis itself.00Inspirational interviews with significant creators and major artists are highlights in this book. Learn about their systems, philosophies, patching secrets, performance tips, and passion for modular synthesis.0Besides a comprehensive introduction to synthesis and its history, the book covers systematic sections on concepts, purpose and creative possibilities of specific modules. Colorful diagrams, presentations of both popular and rare modules, semi-modular and software, as well as techniques for patching and how to get started, are provided.00Foreword by Suzanne Ciani.
Patch & Tweak with Moog is the ultimate resource for Moog synthesizer enthusiasts and musicians of all skill levels interested in an immersive modular synthesis experience. Opening with a foreword from acclaimed film score composer Hans Zimmer, this hardcover book by Kim Bjørn features 200 pages full of synthesizer techniques, creative patch ideas, sound design tips, professional artist interviews, in-depth discussions with Moog engineers, and a glimpse into the company's remarkable history. The book's primary focus is Moog's well-loved line of semi-modular analog synthesizers: Mother-32, DFAM, Subharmonicon, Grandmother, and Matriarch. Patch & Tweak with Moog brings readers inside the creative minds of composers, producers, and performing artists like Suzanne Ciani, Trent Reznor, Lisa Bella Donna, Paris Strother, Hannes Bieger, Stranger Things composers Michael Stein and Kyle Dixon, and Moog synthesizer co-inventor Herb Deutsch in detailed interviews featuring patching tips and tricks for musicians of all skill levels.
Look beyond the basics of Mac programming and development to become a Mac power user. When most people think about the Mac, they think about the amazing graphical user interface macOS is known for. However, there is a whole world to explore beneath the hood. This book approaches working directly in the terminal with fun projects and ideas to help turn you into an advanced Mac user. You'll work with Brew (HomeBrew), which gives you the ability to install applications from Linux (and Unix) that can make the terminal more useful. This is important, because a lot of applications have been stripped out of macOS or deprecated. For example, Apple's built-in PHP is usually a major release behind. You'll also customize your terminal to change everything about it, making it your own. The whole world is about personalizing. Why put up with the Apple defaults? Once you have your terminal set up and ready to rock, you'll review the basics of programming on the Mac terminal. This will allow you to get a taste of power scripting. You'll discover the power of bash, PHP, and Python. And then you'll apply those tools to web development. Tweak Your Mac Terminal takes you on a journey into a world of the terminal and its hidden applications. What You'll Learn Customize the terminal to make it perfect for your needs Develop web applications using basic coding skills in the terminal Install HomeBrew and by extension Linux and Unix applications Who This Book Is ForMac users who are already very familiar with the GUI and want to go further. This book will especially help starting IT professionals and beginning programmers.
The definitive guide to unlocking the hidden potential of the Windows 7 OS Written by bestselling author and the creator of tweaks.com Steve Sinchak, this unique guide provides you with the ultimate collection of hidden gems that will enable you to get the most out of Windows 7. Packed with more than 400 pages of insider tips, the book delves beneath the surface to reveal little-known ways to tweak, modify, and customize Windows 7 so you can get every ounce of performance from your operating system. Regardless of your experience with tweaking your system, you'll find fascinating and fun tips and tricks for getting under the hood of Windows 7 that will allow you to optimize its appearance, speed, usability, and security. Bestselling author and creator of tweaks.com shows you how to tweak, modify, customize, and take complete control of the new Windows 7 operating system Unlocks hidden gems for optimizing the appearance, speed, usability, and security of the Windows 7 OS Shows you how to customize boot and login screens, supercharge your network and online speed, get rid of features that drive you nuts, fine tune your User Account Protection, and more So roll up your sleeves and take off your gloves so you can take total control over your Windows 7 OS!
The story that inspired the major motion picture Beautiful Boy featuring Steve Carell and Timothée Chalamet. This New York Times bestselling memoir of a young man’s addiction to methamphetamine tells a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery. Nic Sheff was drunk for the first time at age eleven. In the years that followed, he would regularly smoke pot, do cocaine and Ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer in California to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling, heartbreaking, and true story of his relapse and the road to recovery. As we watch Nic plunge into the mental and physical depths of drug addiction, he paints a picture for us of a person at odds with his past, with his family, with his substances, and with himself. It's a harrowing portrait—but not one without hope.